Hand foot and mouth disease and type 1 diabetes
- Abundance of Enteroviruses in the Gut Linked to Type 1 Diabetes Precursor
- Common Virus May Have Ties to Type 1 Diabetes
- New study: protecting against type 1 diabetes
- Viruses that linger in gut could trigger type 1 diabetes
Abundance of Enteroviruses in the Gut Linked to Type 1 Diabetes Precursor
Hydration is Key to Treat Hand, Foot and Mouth Diseaseand
Type 1 diabetes is a chronic disease. In people with type 1 diabetes, cells in the pancreas that make insulin are destroyed, and the body is unable to make insulin. Your body gets glucose from the food you eat. When the cells have enough, your liver and muscle tissues store the extra glucose , also called blood sugar, in the form of glycogen. In type 1 diabetes, the body is unable to process glucose, due to the lack of insulin. This leaves too much glucose circulating in your blood.
A new study has investigated how exposure to certain triggers can increase the risk of type 1 diabetes. Researchers from The Westmead Institute for Medical Research are looking at an array of potential triggers that could increase the risk of type 1 diabetes. Results of a recent study have shown how exposure to coxsackievirus can increase this risk. Coxsackievirus is a common virus that causes diseases including myocarditis, Hand, Foot and Mouth Disease and gastroenteritis. The study discovered a key transcription factor proteins that help turn specific genes on or off called hypoxia inducible factor 1-alpha HIF-1A is behind this increase in risk. The findings highlight HIF-1A as a potential pathway for the development of new preventative measures and suggest the possibility that a vaccine for coxsackievirus could help prevent type 1 diabetes in at-risk people.
May 22 UPI -- Researchers say there may be triggers to the genetically linked type 1 diabetes, identifying one potential trigger in a new study. Coxsackievirus is also known for causing Hand, Foot and Mouth disease, gastroenteritis and myocarditis. These cells are responsible for creating insulin, which regulates blood glucose. A transcription factor is a protein that can help activate or deactivate certain genes in the body. So potential preventative strategies are exciting. Health News. By Tauren Dyson.
Common Virus May Have Ties to Type 1 Diabetes
NCBI Bookshelf. Mark A.
New study: protecting against type 1 diabetes
Get the content you want anytime you want. Nonpolio enteroviruses made the news in after 1 enterovirus was linked to an outbreak of acute flaccid myelitis in Colorado children. Although enteroviruses can also cause illnesses such as hand, foot, and mouth disease, the recent study published in the journal Scientific Reports adds to the evidence linking these viruses to childhood-onset type 1 diabetes, once known as juvenile diabetes. According to the US Centers for Disease Control and Prevention CDC , there are nearly 18, children and adolescents younger than 20 years diagnosed with type 1 diabetes annually. There is currently no known way to prevent type 1 diabetes. The children were part of a prospective birth cohort, known as the Australian Viruses in the Genetically at Risk study, with at least 1 first-degree relative with type 1 diabetes. Using a viral sequencing tool that is up to 10, times more powerful at identifying viruses than conventional sequencing methods, the study team identified viruses in the fecal samples that were more abundant in the guts of children with islet autoimmunity compared with age and gender-matched controls.
Researchers at the Center for Infection and Immunity CII at the Columbia University Mailman School of Public Health and the University of New South Wales, Sydney, Australia, provide new evidence supporting an association between elevated levels of enteroviruses in the intestinal tracts of children and islet autoimmunity, a precursor to Type 1 diabetes. The paper appears in the journal Scientific Reports. Approximately 40, cases of Type 1diabetes are diagnosed each year in the U. In Australia, where the study cohort originated, almost 60 percent of newly diagnosed cases are in children and people younger than 25 years. Researchers examined blood and feces collected from 93 children as part of the Australian Viruses In the Genetically at Risk study VIGR , a prospective birth cohort of children with at least one first-degree relative with Type 1 diabetes. The study used Virome-Capture-Sequencing for Vertebrate-infecting viruses VirCapSeq-VERT , a viral sequencing tool developed at the CII that is up to 10, times more powerful at identifying viruses than conventional high-throughput next generation sequencing methods.
We respect your privacy. From Finland comes more evidence that a common group of viral infections may play a role in the development of at least some cases of type 1 diabetes. The viruses are known as enteroviruses. These viruses cause a number of infections -- from the common cold to conditions as serious as polio, according to the U. Centers for Disease Control and Prevention. The study found that children who had signs indicating they might be developing type 1 diabetes had significantly more enterovirus infections occurring at least a year earlier.
Viruses that linger in gut could trigger type 1 diabetes